Ironmouse had originally planned to pursue a career as an opera singer(Soprano), but was later diagnosed with common variable immunodeficiency (CVID)—an immune disorder that has left her largely bedridden. This has required her to remain isolated from others—a situation which intensified in 2020 amid the onset of the COVID-19 pandemic. In 2017, she began to pursue a career as a streamer instead, as she was "lonely and wanted something to do". Hesitant to use her real face online, she was inspired by the Japanese entertainer Kizuna AI—the first YouTuber to refer to themselves as a "virtual YouTuber"—to stream with a digital avatar to conceal her identity.
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In December 2022, she was listed among the "heroes" on the Plasma Hero website for raising awareness about CVID and encouraging viewers to donate plasma. She has also received praise for encouraging donations to The Immune Deficiency Foundation (IDF), a charitable organization which helps people suffering from conditions like hers through research and improving the quality of life of people suffering from primary immunodeficiency.